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HAI Superbugs Clostridium Difficile Anaerobic Bacteria |
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| Last-Modified: 06/01/06 14:48 - |
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Clostridium Difficile, another Superbug to rival MRSA

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A toxin/antitoxin kit for the detection of Clostridium Difficile toxin in faecal specimens. After treatment with antibiotics, many patients develop gastrointestinal problems ranging from mild diarrhea to severe pseudomembranous colitis. Many cases of the milder forms of gastrointestinal illness and most cases of pseudomembranous colitis are caused by Clostridium difficile. The organism is an opportunistic anaerobic bacterium that grows in the intestine once the normal flora has been altered by antibiotics. Clostridium difficile produces two toxins, A and B. Toxin B, often referred to as the cytotoxin, is the toxin detected by the tissue culture assay. The C. difficile Toxin/Antitoxin Kit uses a tissue culture format to detect the presence of cytotoxic activity (cell rounding) in fecal specimens and confirms the identification of C. difficile toxin by using specific antitoxin. Reagents in the kit include toxin control and specific antitoxin. |
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HAI Superbugs Clostridium Difficile Anaerobic Bacteria |
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Clostridium. A group of anaerobic Bacteria. Anaerobic Bacteria can thrive in the absence of oxygen. There are 100+ species types of Clostridium. They include, the most well know, up and coming Superbug, Clostridium Difficile, but also the lesser known Clostridium Perfringens, AKA, Clostridium Welchii, and Clostridium Botulinum. |
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Clostridium Difficile, is now recognized as the chief cause of HAI - Diarrhea in the US and Europe, and not only in hospitals but also in nursing homes and other facilities for long term care. Initial recognition of this disease began in the 1970s, with reports of a serious, sometimes lethal, colitis characterized by the formation of pseudo-membranous plaques. The cause was identified as Clostridium Difficile in 1978. |
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A prolonged course of antibiotics or the use of two or more antibiotics in combination increases the risk of Clostridium Difficile. The cephalosporin antibiotics are the leading instigators of Clostridium Difficile. In most other people, a biological poison is produced, that causes vomiting, diarrhoea, dehydration and stomach pains.
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In 2005, following a pattern seen in other Superbugs, a new and more virulent strain of a potentially fatal hospital infection is being seen in the NHS. At one internationally famous hospital, 12 patients have died, and over 300 have been infected since 2003. Clostridium Difficile, which causes severe diarrhea, mainly affects elderly people, although the new strain has also affected younger patients. Health experts said measures to stop the bug spreading amongst patients have been introduced. It usually affects the elderly, and can prove fatal if antibiotic treatment fails to kill all the spores in the gut, and they take hold again even before the patient's own gut bacteria has had chance to mount a resistance. |
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